POS-443 EXTRA DOMAIN A-SPLICED FIBRONECTIN VARIANT CONTRIBUTES TO TUBULO-INTERSTITIAL FIBROSIS IN A MURINE MODEL OF CHRONIC KIDNEY DISEASE

Chronic Tubulo-interstitial Pyelonephritis with Retroperitoneal Fibrosis.

A large proportion of patients with retroperitoneal fibrosis (RPF) have been labelled as having idiopathic RPF historically. Recent reports of a subset of these patients having a fibro-inflammatory condition with characteristic histology and good response to therapy has helped in renewed understanding of an old disease. A 40 year old man presented with vague abdominal discomfort of 5 months dur...

Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model.

Pathophysiology of Chronic Tubulo - Interstitial Disease in Rats

The human end-stage kidney and its experimental analogue, the remnant kidney in the rat, exhibit widespread tubulointerstitial disease. We investigated whether the pathogenesis of such tubulo-interstitial injury is dependent upon adaptive changes in tubular function and, in particular, in ammonia production when renal mass is reduced. Dietary acid load was reduced in 143nephrectomized rats by d...

Axl Tyrosine Kinase Protects against Tubulo-Interstitial Apoptosis and Progression of Renal Failure in a Murine Model of Chronic Kidney Disease and Hyperphosphataemia

Chronic kidney disease (CKD) is defined as the progressive loss of renal function often involving glomerular, tubulo-interstitial and vascular pathology. CKD is associated with vascular calcification; the extent of which predicts morbidity and mortality. However, the molecular regulation of these events and the progression of chronic kidney disease are not fully elucidated. To investigate the f...

Oral Submucous Fibrosis: A Chronic Deliberating Disease of Oral Cavity

Oral submucous fibrosis is chronic progressive condition of oral cavity. The condition is well recognized for its malignant potential. Usually the disease initiates with redness, blistering, and ulceration inside the mouth. It is characterized by progressive fibrosis of submucosal tissue. The pathogenesis of oral submucous fibrosis is not well understood. Betelquid chewing is the major etiologi...